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目的探讨奥氮平合并西酞普兰对脑卒中后抑郁症患者日常生活质量及神经功能恢复的影响。方法采用抑郁症状自评量表(SDS)对110例脑卒中患者进行抑郁症状态的评定,对其中患有脑卒中后抑郁症的51例患者分别给予奥氮平合并西酞普兰治疗(治疗组)以及安慰剂组(对照组)。分别采用汉密尔顿抑郁症量表(HAMD)、斯堪的那维亚脑卒中量表(SSS)和Barthel指数(BI)评测各组治疗前后的疗效。结果本研究中急性脑卒中患者卒中后抑郁症患病率为46.4%,治疗组SSS评分、HAMD减少,而BI评分增加,与对照组进行比较差异均有统计学意义(P<0.05)。结论脑卒中后抑郁症症患者给予奥氮平合并西酞普兰治疗能提高患者神经功能恢复程度和生活质量的恢复。
Objective To investigate the effect of olanzapine combined with citalopram on the quality of life and the recovery of neurological function in patients with post-stroke depression. Methods The Depression Symptom Checklist 90 (SDS) was used to assess the status of depression in 110 stroke patients. Fifty-one patients with post-stroke depression were assigned to receive olanzapine plus citalopram (treatment group ) And placebo (control group). The Hamilton Depression Rating Scale (HAMD), Scandinavia Stroke Scale (SSS) and Barthel Index (BI) were used to evaluate the curative effect before and after treatment. Results The prevalence of post-stroke depression was 46.4% in patients with acute stroke in this study. The SSS score and HAMD in the treatment group decreased while the BI score increased. There was significant difference compared with the control group (P <0.05). Conclusions Olanzapine plus citalopram administered to patients with post-stroke depression can improve recovery of neurological function and quality of life.