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~(14)C-久效磷在小鼠体内的动力学研究发现,灌胃后血中毒物浓度-时间曲线符合一级吸收两室开放模型。主要动力学参数:T_(1/2)K_α 0.04h,T_(1/2α) 0.39 h,T_(1/2β) 4.78h,Vd1.06L/kg,Cl 0.15L/kg·h,AUC 20.06 mg/L·h。经矩量分析计算,其动力学参数与室模型基本接近。人体的~(14)C-久效磷广泛分布于各脏器和组织,以肝、肾含量最高,脑、脂肪含量最少,未显示亲脂性。~(14)C-久效磷主要经肾脏排出,经胃肠道吸收快,分布快,排出也快,与其快速产生毒效应的一过性相一致。
~ (14) C-monocrotophos in mice kinetics study found that gavage poisoning concentration-time curve in line with the first-absorption two-compartment open model. The main kinetic parameters were as follows: T_ (1/2) K_α 0.04h, T_ (1 / 2α) 0.39 h, T_ (1/2) β 4.78h, Vd1.06L / kg, Cl 0.15L / kg.h, AUC 20.06 mg / L · h. The result of moment analysis shows that the kinetic parameters are basically close to the chamber model. The body of ~ (14) C monocrotophos is widely distributed in various organs and tissues, with the highest content of liver and kidney, brain, fat content of at least, did not show lipophilicity. ~ (14) C- Monocrotophos excreted mainly by the kidneys, absorption through the gastrointestinal tract fast, fast distribution, discharge is also fast, with its rapid toxic effect of a transient consistent.