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目的 :探讨尿纤维结合蛋白 (Fn)水平变化在原发性肾病综合征中的临床意义。方法 :采用ELISA法对2 8例原发性肾病综合征患者和 15例正常对照组进行尿Fn水平检测 ,比较分析其相互之间的差异及激素治疗前后的变化。结果 :原发性肾病综合征患者尿Fn水平为 42 3.46± 2 74.2 7ng/ml,明显高于正常对照组2 1.32± 15 .17ng/ml(P <0 .0 1) ,并且激素敏感型患者尿Fn水平治疗前为 44 9.2 9± 32 6 .79ng/ml,明显高于治疗后 180 .6 9± 71.0 9ng/ml(P <0 .0 1) .结论 :尿Fn化可作为原发性肾病综合征患者判断疗效及估计预后的重要指标之一。
Objective: To investigate the clinical significance of urinary fibronectin (Fn) level changes in primary nephrotic syndrome. Methods: Urine Fn levels were detected by ELISA in 28 patients with primary nephrotic syndrome and 15 normal controls. The differences between them and the changes before and after hormone therapy were compared. Results: The urinary Fn level in patients with primary nephrotic syndrome was 42 3.46 ± 2 74.2 7 ng / ml, which was significantly higher than that of the control group (2.32 ± 15.17 ng / ml, P <0.01), and the hormone-sensitive patients The urinary Fn level before treatment was 44 9.2 9 ± 32 6 .79 ng / ml, which was significantly higher than that of 180 69 ± 71.0 9 ng / ml after treatment (P0.01) .Conclusion: Urinary Fn can be used as primary Nephrotic syndrome patients to determine the efficacy and prognosis of one of the important indicators.