原发性开角型青光眼 (primary open-angle glaucoma, POAG)是一种常染色体显性或隐性遗传倾向的眼病。据世界卫生组织统计分析,全世界眼压大于2.80kPa(21mmHg)者约有10400多万人,POAG约有6680多万人,其中因POAG致盲者约670万人。在中国青光眼的致盲率为22.7％,居第二位。大量证据POAG患者约13％～47％有家族史,其亲属中的发生率约为2.8％～16.5％,发病率明显高于正常群体。随着分子遗传学的发展与人类基因组 Primary open-angle glaucoma (POAG) is an ocular disease of autosomal dominant or recessive genetic predisposition. According to the World Health Organization statistics, about 10400 million people with an IOP greater than 2.80 kPa (21 mmHg) worldwide, about 66.8 million POAGs, of whom about 6.7 million are blind due to POAG. Glaucoma in China blinding rate of 22.7%, ranking second place. Large evidence of POAG patients, about 13% to 47% have a family history of their relatives in the incidence of about 2.8% to 16.5%, the incidence was significantly higher than the normal population. With the development of molecular genetics and the human genome