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为比较两种国产降压药物卡维地洛降压疗效与安全性 ,采用开放性的研究方法 ,比较两组患者在治疗前后的血压、心率以及生化指标的变化。结果显示两组患者在每周的血压、心率、有效率构成、生化指标以及药物不良反应发生率等均无显著性差异 (P>0.05),而各组治疗第4周后与治疗前对比则差异均极为显著(P<0.01) ,收缩压及舒张压下降幅度达14 %以上。因此 ,两家国产卡维地洛制剂安全性较好 ,具有明显的、相似的降压疗效 ,可以作为治疗轻中度高血压病的一线用药。
To compare the antihypertensive effect and safety of two domestic antihypertensive drugs carvedilol, an open study was conducted to compare the changes of blood pressure, heart rate and biochemical indexes in two groups before and after treatment. The results showed that there was no significant difference (P> 0.05) between the two groups in the weekly blood pressure, heart rate, effective rate composition, biochemical indicators and the incidence of adverse drug reactions (P> 0.05) The difference was extremely significant (P <0.01), systolic blood pressure and diastolic blood pressure decreased by more than 14%. Therefore, the two domestic carvedilol preparations better safety, with obvious, similar antihypertensive effect, can be used as a first-line treatment of mild to moderate hypertension medication.