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探讨烫伤宁是否具有镇痛抗炎作用，为其冶疗烫伤提供药效学依据。采用小鼠扭体、激光致痛等模型观察烫伤宁的镇痛效果，用小鼠耳肿法观察烫伤宁外用对急性渗出性炎症的影响。结果为烫伤宁无论灌胃或腹腔注射原药及稀释２～８倍（按０２ｍＬ／１０ｇ体重给药），均显著抑制小鼠扭体反应；大鼠浅Ⅱ°烫伤创面外涂烫伤宁原药及稀释４、１６倍药液１ｍＬ，可显著提高激光致痛的痛阈。正常耳廓涂药不能对抗二甲苯所致耳肿胀。
To investigate whether the scald injury has analgesic and anti-inflammatory effects and provide a pharmacodynamic basis for its scald treatment. The writhing mice and laser induced pain models were used to observe the analgesic effect of Zuolianning. The effects of Zuoyining external use on acute exudative inflammation were observed by mouse ear swelling method. The result was scald rather than intragastric or intraperitoneal injection of the original drug and dilute 2 to 8 times (according to 0 2mL / 10g body weight administration), were significantly inhibited writhing reaction in rats; The original drug and dilution 4,16 times the liquid 1mL, can significantly increase the pain caused by laser pain threshold. Application of the normal auricle can not be resistant to xylene-induced ear swelling.