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对4个厂家9个批号的银黄片用转篮法测定其中黄芩甙、绿原酸的溶出速率,经方差分析表明,两成分的T50、Td、m值不同厂家不同批号样品间均具显著性差异(P<0.01),同一厂家不同批号间也具显著性差异(P<0.01)。并且这两种成分的T50与崩解时限无显著相关性(P>0.01)。同时,比较了黄芩甙与绿原酸间溶出速率关系,二者相关性显著
The dissolution rate of Astragalus membranaceus and chlorogenic acid was determined by transfer basket method on the yellow yellow tablets of 9 batches of 4 manufacturers. The analysis of variance showed that the T50, Td, and m values of the two components were different among different batches of samples from different manufacturers. Differences (P<0.01), there were also significant differences between batch numbers of the same manufacturer (P<0.01). And there was no significant correlation between the T50 and the disintegration time (P>0.01). At the same time, the dissolution rate relationship between Astragalus membranaceus and chlorogenic acid was compared and the correlation between them was significant.