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目的了解血液学参数对儿童珠蛋白生成障碍性贫血(又名地中海贫血)筛查的价值。方法对云南省德宏州傣、景颇、德昂、阿昌族7岁以下儿童共2 171人进行了血液分析、血红蛋白(Hb)电泳检测,并进行统计学分析。结果各检测项目单项检测在筛查诊断珠蛋白生成障碍性贫血中的评价,以红细胞平均体积(MCV)和红细胞平均血红蛋白含量(MCH)的灵敏度为高,以红细胞体积分布宽度(RDW-CV)和Hb的特异度和正确率居首;联合检测珠蛋白生成障碍性贫血结果及评价:平行检测及系列检测的正确率β-珠蛋白生成障碍性贫血均优于α-珠蛋白生成障碍性贫血。结论在同等条件下,采用MCH筛查珠蛋白生成障碍性贫血是可取的建议,要提高特异度和正确率,需降低MCV和MCH的截断点;如果RDW与MCV或MCH联合对珠蛋白生成障碍性贫血进行筛查,可提高正确率,减少漏诊率和误诊率,还能对珠蛋白生成障碍性贫血和缺铁性贫血作鉴别诊断。
Objective To understand the value of hematologic parameters in the screening of children with thalassemia (aka thalassemia). Methods A total of 2 171 children under 7 years of age from Dai, Jingpo, Deang and Achang of Dehong prefecture in Yunnan province were tested for blood and hemoglobin (Hb), and statistical analysis was made. Results The single item test of each test item was used in the evaluation of screening for the diagnosis of globinogenesis-induced anemia. The sensitivity of MCV and MCH was high, and the distribution of RDW-CV (erythrocyte volume distribution) And Hb specificity and accuracy of the first; combined detection of gemoglobulinectomy anemia results and evaluation: the parallel detection and the correctness of the series of detection β-globin aplastic anemia are better than α-globinblastic anemia . Conclusions Under the same conditions, it is advisable to use MCH to screen for aplastic anemia. To improve the specificity and correct rate, it is necessary to reduce the cut-off point of MCV and MCH. If RDW and mitochondrial dystrophin are associated with MCV or MCH, Sex anemia screening, can improve the accuracy, reduce the rate of misdiagnosis and misdiagnosis, but also on the differential diagnosis of globin-induced anemia and iron deficiency anemia.