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目的研究艾滋病合并慢性丙型肝炎患者HIV RNA水平及T淋巴细胞亚群变化情况,为患者早期治疗提供依据。方法选取80例艾滋病合并慢性丙型肝炎住院患者为研究组,80例单纯艾滋病患者为对照组。比较两组患者的HCV RNA水平及T淋巴细胞亚群变化。结果研究组的HIV RNA为(5.35±1.29)loglocopies/m L,高于对照组(4.81±1.15)loglocopies/m L的水平(P<0.05)。研究组HCV RNA水平与HIV RNA水平呈正相关(r=0.372,P<0.05),其CD+4、CD+4/CD+8分别与HIV RNA水平呈负相关(r=-0.533和-0.414,P均<0.05),但CD+4、CD+4/CD+8水平与HCV RNA水平间未见相关性(r=-1.143和-0.119,P>0.05)。对照组的CD+4及CD+4/CD+8与HIV RNA水平呈负相关(r=-0.433和-0.536,P均<0.05)。结论艾滋病合并慢性丙型肝炎患者的HIV RNA复制更活跃,且T淋巴细胞亚群损害更明显,及早治疗丙肝有利于艾滋病患者免疫重建,降低HIV RNA水平。
Objective To study HIV RNA level and T lymphocyte subsets in patients with AIDS and chronic hepatitis C and provide basis for early treatment. Methods 80 cases of AIDS patients with chronic hepatitis C were selected as the study group, 80 cases of AIDS patients as the control group. HCV RNA levels and T lymphocyte subsets were compared between the two groups. Results The HIV RNA in the study group was (5.35 ± 1.29) loglocopies / m L, which was higher than that in the control group (4.81 ± 1.15) loglocopies / m L (P <0.05). The level of HCV RNA in the study group was positively correlated with the level of HIV RNA (r = 0.372, P <0.05). The level of HIV RNA in the study group was negatively correlated with the level of HIV RNA (r = -0.533 and -0.414, P <0.05). However, no correlation was found between the levels of CD + 4, CD + 4 / CD + 8 and HCV RNA (r = -1.143 and -0.119, P> 0.05). The levels of CD + 4 and CD + 4 / CD + 8 in the control group were negatively correlated with HIV RNA levels (r = -0.433 and -0.536, P <0.05). Conclusions HIV RNA replication is more active in patients with AIDS and chronic hepatitis C, and T lymphocyte subsets are more damaged. Early treatment of hepatitis C is beneficial to immune reconstruction of AIDS patients and lower HIV RNA level.