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目的探讨FPG对T2DM患者红细胞(RBC)变形及免疫功能的影响。方法利用新型显微成像与动静态图像分析系统对单个活态RBC形态及膜弹性进行测量,运用酵母菌花环试验对RBC的免疫功能进行测定。测量正常(NC)组和T2DM 7个FPG水平组RBC的形态、膜弹性及免疫功能参数。结果 T2DM各组圆度因子、膜弹性参数及RBC免疫复合物结合花环率(RBC-ICRR)均高于NC组,RBC膜上C3b受体结合花环率(RBC-C3bRR)低于NC组(P<0.05);随FPG上升,圆度因子、膜弹性参数及RBC-ICRR增加,而RBC-C3bRR减小,在FPG较低(FPG<9.0mmol/L)的非相邻两组间差异有统计学意义(P<0.05)。结论随FPG上升,RBC变形及免疫功能减弱。
Objective To investigate the effect of FPG on the erythrocyte (RBC) degeneration and immune function in T2DM patients. Methods The morphology and membrane elasticity of a single living RBC were measured by a new microscopic imaging and dynamic and static image analysis system. The immune function of RBC was tested by yeast wreath. The morphology, membrane elasticity and immune function parameters of RBC in normal group (NC) and 7 FPG in T2DM group were measured. Results The roundness factor, membrane elasticity parameter and RBC-ICRR of T2DM were higher than those of NC group. The RBC-C3bRb of C3b receptor on RBC membrane was lower than that of NC group (P <0.05). With the increase of FPG, roundness factor, membrane elasticity parameter and RBC-ICRR increased, while RBC-C3bRR decreased. There was statistical difference between non-adjacent two groups with lower FPG (FPG <9.0mmol / L) Significance (P <0.05). Conclusion With the increase of FPG, the deformation and immune function of RBC are weakened.