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心脏直视手术时用于心脏停跳和保护的灌注液种类很多,其组成成分虽不同,但基本原则相同。第一是溶液中的停跳剂应使心脏迅速静止;第二是溶液中的保护剂能对抗缺血的有害后果。冠状动脉灌注液的组成似应尽可能接近正常的细胞外液组分。目前,有些溶液中镁的浓度高达160毫克分子,有的溶液则完全无镁。鉴于正常人血浆镁的浓度是每升0.5～1.5毫克分子,作者认为必需明确灌注液中镁的合适浓度。本文报道用离体鼠心模型对这一问题的研究结果。方法:从Wistar种的雄鼠取出心脏按Langen-dorff的方式作左心制备。先记录主动脉和冠状动脉血流量、主动脉峰压、和心率作为对照值。然后灌注停跳-保护溶液2分钟,经过适当缺血停跳期
There are many types of perfusate for cardioplegia and protection during open heart surgery. Although their composition is different, the basic principles are the same. The first is that the cardioversion in solution should allow the heart to quiesce rapidly and the second is that the protective agent in solution counteracts the harmful effects of ischemia. The composition of coronary perfusions seems to be as close as possible to normal extracellular fluid components. At present, some solutions contain up to 160 milligrams of magnesium and some are completely magnesium-free. In view of normal plasma magnesium concentration is 0.5-1.5 milligrams per liter, the authors believe that the appropriate concentration of magnesium in perfusion solution must be clear. In this paper, we report the results of this study using an isolated rat model. METHODS: The heart was removed from a Wistar male and left heart was prepared as Langen-dorff. Aortic and coronary blood flow, aortic peak pressure, and heart rate were recorded as controls. Then perfusion arrest - protection solution for 2 minutes, after appropriate ischemia and arrest period