以选择性环氧化酶-2(COX-2)抑制剂Celecoxib为先导,根据其构效关系和分子模拟研究结果,应用生物电子等排原理等药物设计方法,设计合成了19个结构全新的二芳基取代-1,2,4-三唑类衍生物,其结构经IR,1H NMR,MS和元素分析确证.初步的药理试验结果表明,部分目标化合物具有一定的抗炎活性. Based on the structure-activity relationship and molecular simulation results, a new cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, was used as the guide. By using the bioisosterism principle and other drug design methods, 19 new structures The structures of these compounds were confirmed by IR, 1H NMR, MS and elemental analysis.The results of preliminary pharmacological experiments showed that some of the target compounds had some anti-inflammatory activity.