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探讨根治放射治疗对青少年鼻咽恶性肿瘤远期生存质量的影响。方法 5 1例年龄 <18岁的青少年鼻咽恶性肿瘤在本院接受根治放射治疗 ,随访超过 10年。结果 10年生存率为 5 1.0 %。成年后平均身高、体重男性为 1.6 6m ,5 7kg ,女性为 1.5 5m ,5 3kg。 11人已结婚生育 ,后代均正常。无癌生存 2 6例中后遗症为面部放射性皮炎 2例 (7.7% )、龋牙 6例 (2 3 .1% )、传导性耳聋2例 (7.7% )、颈部放射性皮炎 5例 (19.2 % )、垂体功能减退 2例 (7.7% )。结论 根治性放射治疗对青少年鼻咽恶性肿瘤远期生长发育影响不大 ,较合适的剂量为鼻咽部 6 7～ 6 8Gy ,上颈部 5 5～ 6 5Gy ,下颈部 45～ 5 0Gy。要注重康复期的心理治疗。
To investigate the effect of radical radiotherapy on the long-term quality of life of nasopharyngeal malignant tumors in adolescents. Method 5 One case of adolescent nasopharyngeal malignant tumor, aged <18, underwent radical radiotherapy at our hospital for more than 10 years. Results The 10-year survival rate was 5 1.0%. Adult average height, weight of men 1.6 6m, 57kg, women 1.55m, 53kg. 11 people have been married, offspring are normal. There were 2 cases (7.7%) of facial radiodermatitis, 6 cases (23.1%) of carious tooth, 2 cases of conductive deafness (7.7%) and 5 cases of radiotherapy dermatitis (19.2% ), Pituitary dysfunction in 2 cases (7.7%). Conclusions Radical therapy has little effect on the long-term growth and development of nasopharyngeal malignant tumors in adolescents. The most suitable doses are 67 to 68 Gy in nasopharynx, 45 to 65 Gy in the upper neck and 45 to 50 Gy in the lower neck. Should pay attention to the rehabilitation of psychotherapy.