硝唑眯(Niridazole)即1-(5-硝基-2-噻唑)-2-咪唑啉酮,是一血吸虫性腺致毒物,小剂量时它抑制精子发生,较大剂量能使睾丸坏死。小鼠和大鼠口服硝唑咪有可逆性抑制精子发生作用。最近研究指出硝唑眯在雄性小白鼠中可引起暂时性的不育。本文报道硝唑咪对雄性小白鼠在受精和早期胚胎发育上的定量关系。实验采用任意饲养的IGR-Ha型瑞士小白鼠,雄雌鼠年龄均为8—10周。试验雄鼠腹腔注射700毫克/公斤(LD_(25))硝唑咪的0.1毫升甘油三辛酸酯悬 Niridazole is 1- (5-nitro-2-thiazolyl) -2-imidazolidinone, which is a gonadal toxic to schistosomiasis. It inhibits spermatogenesis at low doses and causes necrosis at higher doses. Oral nitazoxanide in mice and rats reversibly inhibits spermatogenesis. Recent research indicates that nitidine in male mice can cause temporary infertility. This article reports the quantitative relationship between diniconazole and male mice during fertilization and early embryo development. The experiment was conducted with any IGR-Ha type Swiss mouse, both male and female, aged 8-10 weeks. Experimental male mice were injected intraperitoneally with 700 mg / kg (LD_ (25)) nifedipine 0.1 ml of glycerol trioctanoate