目的:对乳癖消巴布膏的处方及制备工艺进行研究。方法:采用正交实验设计,以芍药苷含量为指标优化提取工艺。结果:最佳提取工艺为回流提取二次,第一次加6倍量乙醇,提取2 h,第二次加4倍量乙醇,提取1.5 h。结论:经过优化后制备的乳癖消巴布膏各项指标符合药典规定,工艺重复性好,适于规模化生产。 Objective: To study the prescription and preparation technology of Rupixiao Babu cream. Methods: Orthogonal design was used to optimize the extraction process using paeoniflorin as an index. Results: The optimal extraction process was secondary extraction with refluxing. The first addition of 6-fold ethanol, extraction for 2 h, the second addition of 4-fold ethanol, and extraction for 1.5 h. Conclusion: After optimization, each index of Rupixiao Babu cream complies with Pharmacopoeia regulations, and has good process repeatability and is suitable for large-scale production.