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目的了解2008～2011年广州市手足口病发病人群手足口病重复感染情况。方法采用描述性流行病学研究方法对2008～2011年广州市手足口病重复感染病例进行分析。结果 2008～2011年广州市共有1711名手足口病重复感染病例,重复感染病例发生率3.36%,每次感染均为实验室确诊病例105例,首次感染不同的肠道病毒后,二次感染手足口病病毒类型差别有统计学意义(χ2=25.233,P<0.001)。结论手足口病重复感染实验室结果证实了导致手足口病的肠道病毒之间感染后不能形成有效的交叉保护,同一类型肠道病毒感染引起手足口病后是否能获得持久性特异性免疫力需进一步研究。
Objective To understand the recurrence of hand, foot and mouth disease in HFMD patients from 2008 to 2011 in Guangzhou. Methods Descriptive epidemiological methods were used to analyze repeated cases of HFMD in Guangzhou from 2008 to 2011. Results A total of 1711 hand-foot-mouth disease recurrent infections were reported in Guangzhou from 2008 to 2011. The incidence of repeated infections was 3.36%. Each infection was confirmed by laboratory tests in 105 cases. After the first infection of different enteroviruses, Stomatology virus type difference was statistically significant (χ2 = 25.233, P <0.001). Conclusions The laboratory results of repeated-infection of hand-foot-mouth disease confirmed that effective cross-protection could not be formed after enterovirus-induced hand-foot-mouth disease. Whether the same type of enterovirus infection can cause persistent specific immunity after hand-foot-mouth disease Need further study