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为观察早期干预对脑室周围白质软化预后的影响 ,对收住院的 6 3例早产儿进行头颅 B超监测 ,诊断 PVE或 PVL 31例 ,随机分成干预组和对照组。干预组在新生儿早期给胞二磷胆硷 1 0 0 mg/d,静点 7～ 1 0天。于修正月龄 3个月起定期门诊随诊进行运动机能训练 ,对照组常规治疗。随访至修正月龄 1 2个月以上 2 2例。结果显示 :两组轻度无统计学差异 ,而中度干预组 5例均无 CP发生 ;对照组 3例 ,其中 2例发生 CP,1例大运动发育明显延迟 ,统计学处理差异显著 (x2 :4.30 ,P<0 .0 5 ;)。本文提示 :头颅 B超可早期诊断 PVE并预测 CP发生可能性 ,早期干预对预防 CP的发生可能有一定的作用
To observe the effect of early intervention on the prognosis of periventricular leukomalacia, 31 cases of preterm infants admitted to our hospital were monitored by B-mode ultrasound and 31 cases of PVE or PVL were randomly divided into intervention group and control group. The intervention group in the early neonatal citicoline choline 100 mg / d, static point 7 to 10 days. At the age of 3 months, the regular clinic was followed up for motor function training and the control group was routinely treated. Follow-up to revision of the age of more than 12 months 2 2 cases. The results showed that there was no significant difference between the two groups, while none of the 5 patients in the moderate intervention group had CP. There were 3 cases in the control group, of which 2 cases had CP and 1 case had significant motor development delay, the difference was statistically significant (x2 : 4.30, P <0. 05;). This paper suggests that: B-head ultrasound can be early diagnosis of PVE and predict the possibility of CP, early intervention may have a role in the prevention of the occurrence of CP