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目的:探讨芍药甘草汤(Shaoyao Gancao Decoction,SGD)对家兔膀胱平滑肌肌电活动的影响。方法:将40只雄性家兔随机分为5组,每组8只,ig给予低、中、高剂量(4,8,16 g.kg-1)的芍药甘草胃,记录ig药物后30,60,90,120,150 min家兔正常储尿、排尿情况下膀胱肌电活动和膀胱压力的变化,以及二者之间变化的关系。结果:芍药甘草汤中、高剂量组及阿托品阳性对照组3×10-4 g.kg-1能够明显增加家兔膀胱平滑肌肌电活动的电压和膀胱平滑肌收缩时的膀胱压力,与同时间点的空白组比较具有显著性差异(P<0.05)。结论:芍药甘草汤能够调节家兔膀胱平滑肌的肌电活动和膀胱收缩时的膀胱压力,能够影响家兔膀胱平滑肌舒缩功能。
Objective: To investigate the effect of Shaoyao Gancao Decoction (SGD) on the myoelectric activity of bladder smooth muscle in rabbits. Methods: 40 male rabbits were randomly divided into 5 groups with 8 rats in each group. Low, medium and high dose (4, 8 and 16 g.kg-1) 60,90,120,150 min normal rabbit urine storage, urinary urinary bladder electromyography activity and bladder pressure changes, and the relationship between the changes. Results: 3 × 10-4 g · kg-1 of middle-dose and high-dose peony and licorice soup groups and atropine-positive control group could significantly increase the voltage of myoelectric activity of bladder smooth muscle and bladder pressure of bladder smooth muscle during contraction, Of the blank group compared with significant difference (P <0.05). Conclusion: Shaoyao Gancao Decoction can regulate the myoelectrical activity of bladder smooth muscle in rabbits and bladder pressure in bladder contraction, which can affect the contractile function of rabbit bladder smooth muscle.