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乙型肝炎病毒(HBV)感染已经成为一种全球性危害。全球60亿人口中约20亿感染HBV,3.5亿为慢性HBV感染,其中25%～40%最终将死于肝硬化或肝细胞癌,每年因慢性乙型肝炎(CHB)相关疾病而死亡的人数高达100多万例[1～2]。随着CHB慢性化程度的加重其HBeAg阴性慢性乙型肝炎的检出率有增高
Hepatitis B virus (HBV) infection has become a global hazard. About 2 billion of the world’s 6 billion people are infected with HBV and 350 million with chronic HBV infection, of which 25% to 40% will eventually die of cirrhosis or hepatocellular carcinoma, the number of people who die each year from diseases associated with chronic hepatitis B (CHB) Up to more than 100 million cases [1 ~ 2]. With the degree of chronic CHB increased its detection rate of HBeAg-negative chronic hepatitis B increased