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近几年来,随着免疫学的迅速发展,人们对于发生在淋巴结外的恶性淋巴瘤发病机制的临床表现、诊断和治疗有更深了解。甲状腺发生的淋巴瘤包括两部分,一是继发性,是全身系统性淋巴瘤累及甲状腺,因为有恶性淋巴瘤的病史,容易诊断。二是原发性,甲状腺是非淋巴造血组织,无发生恶性淋巴瘤的组织学基础,甲状腺原发性恶性淋巴瘤有其独特的发病机制、临床表现、诊断和治疗原则。现综述如下。 1 概述甲状腺原发性恶性淋巴瘤非常少见,文献中多为病例报告,大宗的总结非常少,英国的Pledge等人回顾性总结了20年(1973～1992)的资料,发现甲状腺原发性恶性淋巴瘤43例。国内仅为病例报告。甲状腺原发性恶性淋巴瘤占甲状腺恶性肿瘤的0.6%
In recent years, with the rapid development of immunology, people have a deeper understanding of the clinical manifestations, diagnosis and treatment of malignant lymphomas that occur outside the lymph nodes. Thyroid lymphomas include two parts, one is secondary, systemic lymphoma involving the thyroid, because of the history of malignant lymphoma, easy to diagnose. The second is primary, thyroid is non-lymphoid hematopoietic tissue, no histological basis of malignant lymphoma, and thyroid primary malignant lymphoma has its unique pathogenesis, clinical manifestation, diagnosis and treatment principles. This is summarized below. 1 Overview Primary malignant lymphoma of the thyroid gland is very rare. Most cases in the literature are case reports. There is very little generalization. Pledge and others in the United Kingdom retrospectively summarized data from 20 years (1973 to 1992) and found that the primary malignant thyroid gland There were 43 cases of lymphoma. Only domestic case reports. Primary malignant thyroid lymphoma accounts for 0.6% of thyroid malignancies