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氯霉素作为第一个广谱抗生素自1947年起曾广泛应用于临床,但因其毒性(引起再障)而限制其应用,然而某些临床资料说明氯霉素虽然可造成骨髓损害,但停药后大多数可恢复。本文采用小白鼠口服氯霉素观察对末梢血液有形成分生成的抑制作用,现将结果报告如下。 1 资料与方法小白鼠10只,鼠龄40～60d,雌雄兼有,体重20g。盐酸氯霉素(齐齐哈尔第二制药厂制品)。将小鼠随机编号、称重,开始采用灌胃给药的方法(药物浓度
Chloramphenicol was widely used as the first broad-spectrum antibiotic since 1947, but its use was limited due to its toxicity (induced aplastic anemia). However, some clinical data suggest that chloramphenicol may cause bone marrow damage, but Most can be recovered after drug withdrawal. In this study, mice were orally treated with chloramphenicol to observe the inhibitory effects on the formation of peripheral blood components. The results are reported below. 1 Materials and Methods 10 mice, mouse age 40 ~ 60d, both male and female, weight 20g. Chloramphenicol hydrochloride (products of Qiqihar Second Pharmaceutical Factory). The mice were randomly numbered, weighed, and started to be administered by gavage (drug concentration)