The Large-eddy simulation (LES) with two-way coupling is used to study bubble-liquid two-phase confined multiple jets discharged into a 2D channel. The LES results reveal the large-eddy vortex structures of both liquid flow and bubble motion, the shear-generated and bubble-induced liquid turbulence, and indicate much stronger bubble fluctuation than that of the liquid, the enhancement of liquid turbulence by bubbles. Both shear and bubble-liquid interaction are important for the liquid turbulence generation in the case studied. The Large-eddy simulation (LES) with two-way coupling is used to study bubble-liquid two-phase confined multiple jets discharged into a 2D channel. The LES results reveal the large-eddy vortex structures of both liquid flow and bubble motion, the shear-generated and bubble-induced liquid turbulence, and indicate much stronger bubble fluctuation than that of the liquid, the enhancement of liquid turbulence by bubbles. Both shear and bubble-liquid interaction are for the liquid turbulence generation in the case studied.