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对 78例新生儿缺氧缺血性脑病 (HIE)给予高压氧加综合治疗 ,存活病例随访至 1～ 4岁。采用国内CDCC量表测定智商及神经系统检查 ,复查头颅 CT。对照组 62例 ,仅给综合治疗。结果发现 :高压氧组中、重度 HIE患儿神经症状消失平均时间短于对照组 (P<0 .0 1) ;两组总有效率比较 ,有显著性差异 (P<0 .0 1)。早期高压氧治疗发生脑损害较对照组明显减少 (P<0 .0 1) ,预后不良率低于对照组 (P<0 .0 5) ;晚期高压氧治疗的远期疗效与对照组比较 ,无显著性差异 (P>0 .0 5)。认为高压氧可明显缩短中、重度 HIE患儿病程 ,早期高压氧治疗可降低病死率、减少后遗症的发生及严重程度 ;晚期高压氧治疗对重症患儿不能改善预后。
78 cases of neonatal hypoxic-ischemic encephalopathy (HIE) were given hyperbaric oxygen plus comprehensive treatment, survival cases were followed up to 1 to 4 years old. Using the domestic CDCC measurement IQ and neurological examination, review head CT. Control group of 62 cases, only to the comprehensive treatment. The results showed that in the hyperbaric oxygen group, the average disappearance of neurological symptoms in children with severe HIE was shorter than that in the control group (P <0.01). There was significant difference between the two groups in total effective rate (P <0.01). Compared with the control group, the incidence of brain damage in hyperbaric oxygen therapy was significantly decreased (P <0.01), and the rate of poor prognosis was lower than that in the control group (P <0.05). The long-term efficacy of hyperbaric oxygen therapy in the later period was significantly lower than that in the control group No significant difference (P> 0.05). Hyperbaric oxygen that can significantly shorten the course of HIE in children with early hyperbaric oxygen therapy can reduce the mortality and reduce the incidence and severity of sequelae; hyperbaric oxygen therapy in advanced stage can not improve the prognosis of critically ill children.