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目的 研究 5 氟尿嘧啶 (5 FU)半乳糖神经酰胺 (GalCer)脂质体急性毒性是否存在昼夜节律。方法 分别于 4、10、16、2 2时 ,采用静脉注射 (iv) ,观察小鼠给予包封有 5 FU的GalCer脂质体后所产生的毒性反应和死亡情况 ,计算半数致死量(LD50 )。结果 iv 5 FUGalCer脂质体LD50 分别为 171 0、2 5 2 5、2 70 1和 2 0 2 7mg·kg-1;其 95 %可信区间分别为 15 2 8~190 3、2 2 6 8~ 2 81 1、2 2 2 0~ 32 7 5和 173 1~ 2 36 5mg·kg-1。结论 5 FUGalCer脂质体夜间的急性毒性大于白天 ,存在着明显的昼夜节律现象
Objective To investigate the circadian rhythm of the acute toxicity of 5-fluorouracil (5 FU) galactose ceramide (GalCer) liposome. Methods At 4, 10, 16, and 22 hours, the toxicity and death of GalCer liposome encapsulated with 5 FU were observed by intravenous injection (iv). The LD50 ). Results The LD50 of iv 5 FUGalCer liposomes were 171 0, 25 2 5, 2 70 1 and 2 0 2 7 mg · kg -1, respectively. The 95% confidence intervals of the liposomal iv 5 FUGalCer were 15 2 8 ~ 190 3,2 2 6 8 ~ 2 81 1,2 2 2 0 ~ 32 7 5 and 173 1 ~ 2 36 5 mg · kg -1. Conclusions The acute toxicity of FUGalCer liposomes at night is greater than that of daytime and there are obvious circadian rhythms