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临床使用的抗菌药物日益增加,过去1年中,几种新药已经引入使用,预期许多其他药物来年也将投放市场,其中某些药物属于崭新的化学类型(如单环β内酰胺类和penems),但新的药物不一定意味着更好,我们应用时必须慎重,要清醒地注意到这些药物在上市前仅在几千人身上做过试验,其中严重的或有生命危险的病人仅数百例,而几乎没有在预期将于48h内死亡的病人身上做过试验。
An increasing number of antibiotics are being used clinically and several new drugs have been introduced in the past year. Many other drugs are expected to be available in the coming years, some of which are new to the chemical type (eg, monobactams and penems) , But the new drugs do not necessarily mean better, we have to be cautious when applying them, and be soberly aware that the drugs were tested on just a few thousand people before they went on the market, with only a few hundred being serious or life-threatening Cases, with very few trials on patients expected to die within 48 hours.