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目的 掌握四川省结核病耐药动态及变化趋势 ,评价结核病控制实施效果。方法 对四川省 1985、1990和 2 0 0 0年 3月结核病流调耐药性调查结果进行分析。结果 ① 3次调查结果显示结核病总体、继发耐药率呈下降趋势。②各种药物的耐药发生频率中以INH为最高 ,EMB最低 ;RFP耐药率明显上升 ,INH呈下降趋势。③不同耐药类型的发生频率中耐一药下降 ,含INH +RFP的耐多药率呈上升趋势 ,尤以 2 0 0 0年耐多药率增高明显。结论 四川省结核病总体耐药情况虽呈下降趋势 ,但耐多药率明显增高的情况不容忽视 ,继续贯彻现代结核病控制策略 ,阻止耐药结核病的流行
Objective To understand the trends and trend of drug resistance in tuberculosis in Sichuan Province and evaluate the effect of tuberculosis control. Methods The results of a survey of tuberculosis drug resistance in Sichuan Province in 1985, 1990 and March 2000 were analyzed. Results ① The results of the three surveys showed that the overall rate of TB was declining. (2) INH was the highest and EMB was the lowest in the frequency of drug resistance of all kinds of drugs. The resistance rate of RFP obviously increased and INH showed a decreasing trend. ③ The frequency of resistance to different types of drug resistance decreased, with INH + RFP multidrug-resistant rate is on the rise, especially in 2000 MDR rate increased significantly. Conclusions Although the overall drug resistance of TB in Sichuan Province shows a decreasing trend, the MDR prevalence rate can not be ignored. To continue the implementation of modern TB control strategies to prevent the spread of drug-resistant TB