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目的 对内镜活检胃正常及良、恶性组织中胃泌素样细胞进行了观察和对照研究,并探讨了其临床意义。 方法 消化性溃疡47例,其中胃溃疡28例,十二指肠溃疡19例,胃癌25例及其癌旁非癌粘膜组织经内镜活检获取,胃泌素样细胞的观察采用免疫组化方法。 结果 ①十二指肠溃疡患者G细胞计数为120.7±18.4/mm~2,高于正常(P<0.01),胃溃疡G细胞计数为69.4±6.2/mm~2,与正常相似,(P>0.05)。②癌旁非癌粘膜G细胞计数增高;③28％(7/25)胃癌组织中存在胃泌素样细胞。 结论 ①十二指肠溃疡的发生可能与G细胞增多有关。②胃癌组织中存在胃泌素样细胞的分化。③癌旁G细胞增生可能是胃癌的一种高危征象。
Objective To observe and control gastrodin-like cells in normal gastric mucosa and benign and malignant tissues by endoscopic biopsy and discuss its clinical significance. Methods Forty-seven cases of peptic ulcer, including 28 cases of gastric ulcer, 19 cases of duodenal ulcer, 25 cases of gastric cancer and their adjacent non-cancerous mucosa tissues were obtained by endoscopic biopsy. Gastrin-like cells were observed by immunohistochemistry . Results ① The number of G cells in patients with duodenal ulcer was 120.7 ± 18.4 / mm ~ 2, higher than normal (P <0.01). The G cell count of gastric ulcer was 69.4 ± 6.2 / mm ~ 2, similar to normal (P> 0.05). (2) The number of non-cancerous adjacent mucosa G cells increased; (3) Gastrinoid cells existed in 28% (7/25) gastric carcinomas. Conclusion ① The incidence of duodenal ulcer may be related to the increase of G cells. Gastric cancer cells exist in the differentiation of gastrin-like cells. ③ adjacent to the proliferation of G-cell gastric cancer may be a sign of high risk.