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目的探讨酵母样真菌感染情况及其耐药性,为临床合理使用抗菌药物提供依据。方法采用法国生物梅理埃公司生产的ATB微生物鉴定仪、ID32C真菌鉴定板、ATBFUNGUS3药敏板对临床标本进行真菌鉴定和药敏试验。结果共分离酵母样真菌530株,主要来源痰液、尿液、分泌物及粪便。酵母样真菌中白假丝酵母检出率最高为57.17%,其次为热带假丝酵母、光滑假丝酵母、近平滑假丝酵母及克柔假丝酵母等。酵母样真菌对各类抗菌药的耐药率最高氟康唑、伊曲康唑,两性霉素B最敏感。结论临床酵母样真菌感染以白假丝酵菌为主,临床应根据药敏试验结果合理选用抗真菌药物。
Objective To investigate the prevalence and drug resistance of yeast-like fungi and provide a basis for the rational use of antibacterials in clinic. Methods ATB Microbial Identification Instrument, ID32C Fungi Identification Board and ATBFUNGUS3 Sensitivity Plate were used to identify the fungi and drug susceptibility of clinical specimens. Results A total of 530 yeast-like fungi were isolated, mainly from sputum, urine, secretions and feces. The highest detection rate of Candida albicans in yeast-like fungi was 57.17%, followed by Candida tropicalis, Candida glabrata, Candida parapsilosis and Candida krusei. Yeast-like fungi are the most susceptible to fluconazole, itraconazole and amphotericin B, with the highest rates of resistance to various antibacterial agents. Conclusion The clinical diagnosis of yeast-like fungus is mainly made of Candida albicans, and the clinical use of antifungal drugs should be based on the results of drug susceptibility testing.