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目的:比较不同类型、不同病变支数冠心病患者的血清脂肪细胞型脂肪酸结合蛋白(A-FABP)的血清水平,分析其与冠心病的关系。方法:选择冠心病患者64例,同期造影阴性对照组24例。采用固相夹心酶偶联免疫吸附法(ELISA)检测A-FABP、白细胞介素6(IL-6)含量,免疫散射比浊法测定血清高敏C反应蛋白(hs-CRP)。结果:A-FABP水平在对照组[5.96(4.87～7.99)ng/ml]较冠心病组[7.76(6.28～9.12)ng/ml]明显降低(P<0.05)。A-FABP水平在多支病变组[9.33(8.04～11.09)ng/ml]较单支病变组[6.61(5.62～7.59)ng/ml](P<0.01)高。A-FABP与IL-6呈正相关(r=0.592,P<0.01),与hs-CRP呈正相关(r=0.604,P<0.01)。Logistic回归分析示血清A-FABP水平与冠心病危险度呈正相关(χ2=21.734,P<0.01)。结论:血清A-FABP水平与冠心病的病变程度、IL-6、hs-CRP及冠心病危险度呈正相关。
Objective: To compare the serum levels of serum adipocyte-type fatty acid-binding protein (A-FABP) in patients with different types of coronary heart disease and their relationship with coronary heart disease. Methods: Sixty-four patients with coronary heart disease were selected, and 24 patients with contrast-negative control in the same period. The contents of A-FABP and IL-6 were detected by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA), and the serum hs-CRP was measured by immune nephelometry. Results: The level of A-FABP in the control group [5.96 (4.87-7.99) ng / ml] was significantly lower than that in the coronary heart group [7.76 (6.28-9.12) ng / ml] (P <0.05). The level of A-FABP was higher in multi-vessel disease group (9.33 (8.04-11.09) ng / ml vs 6.61 (5.62-7.59) ng / ml] in single vessel disease group (P <0.01). A-FABP was positively correlated with IL-6 (r = 0.592, P <0.01), and positively correlated with hs-CRP (r = 0.604, P <0.01). Logistic regression analysis showed a positive correlation between serum A-FABP level and risk of coronary heart disease (χ2 = 21.734, P <0.01). Conclusion: Serum A-FABP level is positively correlated with the degree of coronary heart disease, IL-6, hs-CRP and coronary heart disease risk.