抗疟药氯喹是人类生产的最成功的抗微生物药物之一,并已在公共卫生方面发挥了巨大而有益的作用。然而经近半个世纪的应用之后,我们对氯喹如何在分子水平发挥作用及某些疟原虫株如何对它产生抗性仍不了解。Slater和Cerami令人信服的发现表明,氯喹对疟原虫在红细胞内生存所必须的血红素解毒酶产生干扰。疟原虫在红细胞内的迅速增殖所需的营 Anti-malaria chloroquine is one of the most successful antimicrobials produced by humans and has played a huge and beneficial role in public health. However, after nearly half a century of application, we are still not familiar with how chloroquine works at the molecular level and how certain plasmodium strains develop resistance to it. Convincing findings from Slater and Cerami indicate that chloroquine interferes with the heme detoxification enzymes necessary for Plasmodium to survive in erythrocytes. The Campylobacter is required for rapid proliferation within red blood cells