目的　研究PPAR -γ激动剂Troglitazone对高浓度葡萄糖作用的大鼠肾小球系膜细胞mPGEs蛋白表达水平的影响。方法　用高浓度葡萄糖和不同浓度Troglitazone作用大鼠肾小球系膜细胞 ,ELISA法检测上清液中mPGEs浓度。结果　 5 %葡萄糖可使体外培养的大鼠系膜细胞mPGEs蛋白表达水平明显增高 ( P <0 0 5 ) ;10～ 2 0nmol/L的Troglitazone可明显抑制 5 %葡萄糖诱导的大鼠系膜细胞mPGEs蛋白表达水平的增高 (P <0 0 5 )。结论　高浓度葡萄糖可诱导体外培养的大鼠系膜细胞mPGEs蛋白表达水平明显增高 ,PPAR -γ激动剂Troglitazone可明显抑制高糖诱导的大鼠肾小球系膜细胞mPGEs蛋白表达水平的增高 Objective To investigate the effect of Troglitazone, a PPAR-γ agonist, on the expression of mPGEs in glomerular mesangial cells induced by high concentration of glucose. Methods Rat glomerular mesangial cells were treated with high glucose and different concentrations of Troglitazone. The concentrations of mPGEs in the supernatant were measured by ELISA. Results 5% glucose significantly increased the mPGEs expression in rat mesangial cells cultured in vitro (P <0.05). Troglitazone at 10 ~ 200 nmol / L significantly inhibited mPGEs expression in rat mesangial cells induced by 5% glucose The protein expression level increased (P <0 05). Conclusion High glucose can induce mPGEs expression in rat mesangial cells in vitro. Troglitazone, a PPAR-γ agonist, can significantly inhibit the increase of mPGEs expression in rat mesangial cells induced by high glucose