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胎儿在产前的发育过程中,受到损伤染色体的化学物质的作用是特别危险的。胎儿细胞的损害,在生命的早期导致癌肿的发生;生殖细胞系的损害,引起遗传变异的增加。对于在体内具有损伤染色体潜在危险的化学剂,可以用测定染色体无着丝点断片频率的微核试验加以筛选。微核通常在成年啮齿动物骨髓的嗜多色红细胞中观察计数。这一短周期的实验方法,被认为和用来检测化学致畸活性更为繁琐的中期染色体分析法是
The role of fetuses in the prenatal development of the chemicals that are damaged by the chromosomes is particularly dangerous. Fetal cell damage in the early life led to the occurrence of cancer; germ cell damage, causing an increase in genetic variation. For chemicals that have a potential risk of damaging chromosomes in the body, they can be screened by micronucleus tests that determine the frequency of chromosomal no-filament fragments. Micronuclei are often observed in polychromatic erythrocytes in adult rodent bone marrow. This short-cycle experimental method is believed to be more complicated than the metaphase chromosome assay used to detect chemical teratogenic activity