甲硝唑为咪唑类衍生物,对阿米巴滋养体有很强的直接杀灭作用,临床可用于治疗阿米巴痢疾和肝脓肿。甲硝唑口服吸收良好,血浆蛋白结合率为10%～20%,故还常用于治疗酒渣鼻、滴虫病、革兰阴性杆菌感染。其毒性低,副反应常见恶心、上腹绞痛等胃肠道反应,极少发生双硫醒反应。笔者近年来遇到2例,现报道如下。 Metronidazole is an imidazole derivatives, a direct role in the killing of amebic trophozoites, clinically useful for the treatment of amoebic dysentery and liver abscess. Metronidazole oral absorption of good plasma protein binding rate of 10% to 20%, it is also commonly used for the treatment of rosacea, trichomoniasis, Gram-negative bacilli. Its toxicity is low, side effects common nausea, abdominal cramps and other gastrointestinal reactions, rare occurrence of disulfide wake reaction. In recent years, I encountered two cases are reported below.