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目的建立推算乌头碱氨基醇型水解产物含量的方法。方法通过控制苯甲酰乌头原碱水解条件,分别获得不同阶段的水解产物,确定苯甲酰乌头原碱降解率与苯甲酸转化率之间的关系,建立通过苯甲酸HPLC定量分析推导氨基醇型乌头原碱类水解产物含量的方法,并利用该方法对药典法制草乌生物碱含量进行测定。结果苯甲酰乌头原碱降解率与苯甲酸转化率约为1∶1,通过测定苯甲酸含量计算氨基醇型乌头原碱类含量的公式为:氨基醇型乌头原碱类含量≈(苯甲酸的含量×529)/122。药典法制草乌的双酯型生物碱、单酯型生物碱和氨基醇型乌头原碱类含量分别为0.0025%、0.16%和0.005%。结论通过定量分析苯甲酸含量推导乌头碱氨基醇型水解产物含量的方法可行,操作简单。
Objective To establish a method for calculating the content of aconitine amino alcohol hydrolysates. Methods The hydrolysis conditions of benzoyl aconitine were controlled to obtain the hydrolyzed products at different stages respectively. The relationship between the degradation rate of benzoyl aconitine and the conversion of benzoic acid was determined. The quantitative analysis of amino groups by benzoic acid Alcohol aconitum alkaloids hydrolyzate content of the method, and the use of the method of Pharmacopoeia Aconitum alkaloids content were determined. Results benzoyl aconitine alkali degradation rate and benzoic acid conversion rate of about 1: 1, by calculating the benzoic acid content calculated amino alcohol type aconitine alkali content formula is: amino alcohol aconitine alkali content ≈ (Benzoic acid content × 529) / 122. The contents of diester alkaloids, monoester alkaloids and amino alcohol type aconitine alkaloids in A. officinalis were 0.0025%, 0.16% and 0.005%, respectively. Conclusion The method of derivatization of aconitine amino alcohol hydrolysates by quantitative analysis of benzoic acid content is feasible and easy to operate.