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目的探讨足月新生儿动脉导管未闭(PDA)治疗方法及预后情况。方法对符合条件的足月新生儿进行心脏彩色多普勒超声筛查,发现189例PDA。按治疗与否及治疗方法分3组:间歇鼻导管吸氧为治疗组1(77例),口服消炎痛为治疗组2(40例),未治疗组(72例)。分别在出生1-2周、3月、6月复查心脏彩色多普勒超声。结果出生1-2周时3组PDA的关闭率分别为55.84%、70%、36.11%,P(0.05。但2组治疗组间P(0.05。3个月左右三组PDA的关闭率均达到80%以上,6个月关闭率95%左右,P(0.05。结论无症状足月新生儿患PDA于出生早期治疗对加速其功能性关闭有积极意义,而对于其远期的关闭率影响不大,近95%的足月新生儿PDA可自愈。
Objective To investigate the treatment and prognosis of patent ductus arteriosus (PDA) in term neonates. Methods The eligible full-term newborns were examined by color Doppler sonography and found that 189 cases of PDA. According to the treatment or not, the patients were divided into 3 groups: intermittent nasal catheter oxygenation for the treatment group 1 (77 cases), oral indomethacin treatment group 2 (40 cases), untreated group (72 cases). Heart color Doppler ultrasound was reviewed at 1-2 weeks of birth, March, and June respectively. Results The closure rates of three groups of PDA at 1-2 weeks of birth were 55.84%, 70%, 36.11%, P (0.05), but the P between the two treatment groups (the closure rate of all three groups reached 0.05.3 months 80%, 6 months, the closure rate of about 95%, P (0.05. Conclusion Asymptomatic full-term newborns with PDA early neonatal treatment to accelerate the functional closure has a positive effect, and its long-term closure rate does not affect Large, nearly 95% full-term newborns PDA self-healing.