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目的观察多塞平联合奥美拉唑治疗消化性溃疡的临床疗效。方法消化性溃疡患者120例,随机分为治疗组和对照组各60例。治疗组给予多塞平、奥美拉唑治疗,对照组仅给奥美拉唑治疗。4周后行胃镜及活组织检查观察比较两组疗效。结果治疗组症状缓解54例(90.0%)高于对照组46例(76.7%),差异有统计学意义(P<0.01)。治疗组出现口干、口涩2例,嗜睡4例,对照组出现恶心1例。结论多塞平联合奥美拉唑治疗消化性溃疡效果更佳,值得临床推广。
Objective To observe the clinical efficacy of doxepin and omeprazole in the treatment of peptic ulcer. Methods 120 patients with peptic ulcer were randomly divided into treatment group and control group of 60 cases. The treatment group was given doxepin, omeprazole treatment, the control group only omeprazole treatment. Gastroscopy and biopsy were performed 4 weeks later to compare the curative effect of the two groups. Results In the treatment group, 54 cases (90.0%) were relieved of symptoms, compared with 46 cases (76.7%) in the control group, the difference was statistically significant (P <0.01). The treatment group had dry mouth, mouth astringent in 2 cases, drowsiness in 4 cases, nausea in control group, 1 case. Conclusion The combination of doxepin and omeprazole is more effective in treating peptic ulcer and is worthy of clinical promotion.