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巨噬细胞集落刺激因子(M-CSF)能促进单核细胞成熟,刺激成熟单核-巨噬细胞产生其它细胞因子。临床试验表明,纯化人 M-CSF(hM-CSF)能促进化疗和同种骨髓移植后中性粒细胞恢复。作者将 hM-CSF 用于自体骨髓移植(ABMT)患者,以进一步研究该因子的间接刺激造血作用。病人和方法 20例无骨髓受累的恶性淋巴瘤患者,中数年龄32岁。其中何杰金病13例,非
Macrophage colony-stimulating factor (M-CSF) can promote monocyte maturation, stimulating mature monocytes - macrophages to produce other cytokines. Clinical trials show that purified human M-CSF (hM-CSF) can promote neutrophil recovery following chemotherapy and allogeneic bone marrow transplantation. The authors used hM-CSF in autologous bone marrow transplantation (ABMT) patients to further investigate the indirect effects of this factor on hematopoiesis. Patients and Methods Twenty patients with malignant lymphoma without myeloid involvement, the median age of 32 years. Which Hodgkin disease 13 cases, non