论文部分内容阅读
目的：探讨＋Ｇｚ重复作用后大鼠血液流变学特性的变化规律及其在＋Ｇｚ致脑损害中的作用．方法：利用动物离心机将大鼠重复暴露于＋１０Ｇｚ３ｍｉｎ三次，观察暴露后不同时间血液流变学特性及脑组织形态学的变化．结果：＋Ｇｚ重复暴露３次后即刻及１ｈ，大鼠全血粘度、全血还原粘度、血浆纤维蛋白原含量、红细胞聚集指数及屈服应力较对照组均显著升高（Ｐ＜０．０５）；暴露后６ｈ，全血粘度、全血还原粘度及血浆纤维蛋白原含量已基本恢复至对照组水平，红细胞聚集指数及屈服应力也呈现出恢复趋势，但仍明显高于对照组（Ｐ＜０．０５）．＋Ｇｚ暴露后各时间组的血浆粘度、红细胞体积分数、红细胞刚性指数及Ｃａｓｓｏｎ粘度则均无明显变化．＋Ｇｚ重复暴露后大鼠脑皮层少数神经元出现缺血性改变．结论：＋１０Ｇｚ３ｍｉｎ重复暴露３次可引起大鼠血液流变学特性的改变．全血粘度的增高可能主要与红细胞聚集程度增加有关．血液流变学特性的改变可能对加重＋Ｇｚ重复暴露引起的脑损害有一定影响．
Objective: To investigate the changes of hemorheology and the role of + Gz in brain injury induced by + Gz. Methods: The rats were repeatedly exposed to +10 Gz3min three times with an animal centrifuge to observe the changes of hemorheology and brain histomorphology at different time after exposure. Results: Whole blood viscosity, whole blood viscosity, plasma fibrinogen, erythrocyte aggregation index and yield stress were significantly higher than those in the control group (P <0.05). At 6h after exposure, whole blood viscosity, whole blood viscosity and plasma fibrinogen content recovered to the level of the control group. The erythrocyte aggregation index and yield stress also showed a recovery trend, but still significantly higher than that of the control group (P <0. 05). There was no significant change in plasma viscosity, erythrocyte volume fraction, erythrocyte rigidity index and Casson viscosity at each time after + Gz exposure. + Gz repeated exposure of a small number of cerebral cortex neuronal ischemic changes. Conclusion: Repeated exposure of + 10Gz3min for 3 times can cause changes of hemorheology in rats. Elevated whole blood viscosity may be mainly associated with increased levels of erythrocyte aggregation. Changes in hemorheological properties may have some effect on brain damage caused by aggravated + Gz repeated exposures.