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血清阴性重症肌无力是一种异质性疾病。大部分患者仍然是一种神经肌肉接头处自身免疫性疾病，但其发病机制不同于血清阳性重症肌无力。患者血清中的 ＩｇＧ和／或非 ＩｇＧ成分可能均参与了其致病过程，靶抗原也具有多样性。
Seronegative myasthenia gravis is a heterogeneous disease. Most patients remain an autoimmune disease at the neuromuscular junction, but their pathogenesis is different from that of seropositive myasthenia gravis. IgG and / or non-IgG components in serum of patients may all participate in its pathogenic process, and the target antigens also have diversity.