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目的:探讨儿童哮喘在吸入沙美特罗替卡松同时一次性肌肉注射维生素D37.5 mg治疗前后血清25-羟基维生素D[25(OH)D]的变化。方法:选取2012年10月至2014年6月在成都市妇女儿童中心医院哮喘门诊就诊的哮喘急性发作初治患儿69例,采用随机数字表法分为对照组36例和观察组33例。两组均给予沙美特罗替卡松每次一吸(50μg/100μg),2次/天;观察组仅第1天加用维生素D330万IU肌肉注射一次。两组均在治疗前及治疗3个月后取静脉血清采用化学发光法测定25(OH)D水平。结果:观察组治疗后血清25(OH)D水平升高,虽未达到理想水平,但可纠正哮喘患儿存在的25(OH)D不足或缺乏,与治疗前比较差异有统计学意义(P<0.05);对照组治疗前后血清25(OH)D水平比较差异无统计学意义(P>0.05);治疗后观察组血清25(OH)D水平高于对照组(P<0.05)。结论:对哮喘患儿给予一次性维生素D330万IU肌肉注射可以纠正其存在的25(OH)D不足或缺乏,可能是改善哮喘患儿临床预后的积极补充治疗措施。
Objective: To investigate the changes of serum 25-hydroxyvitamin D [25 (OH) D] in asthmatic children before and after inhalation of salmeterol and tacalaside plus one-time intramuscular injection of vitamin D37.5 mg. Methods: From October 2012 to June 2014, 69 children with acute asthma exacerbation who were treated at the Asthma Clinic of Chengdu Women and Children’s Central Hospital were divided into control group (36 cases) and observation group (33 cases) by random number table. Both groups were given salmeterol and fluticasone once a suction (50μg / 100μg), 2 times / day; the observation group only with the first day of vitamin D330 million IU intramuscular injection. The levels of 25 (OH) D in the two groups were measured by chemiluminescence before treatment and 3 months after treatment. Results: The level of serum 25 (OH) D in the observation group increased but did not reach the ideal level, but the deficiency or deficiency of 25 (OH) D in the asthmatic children could be corrected, the difference was statistically significant (P <0.05). There was no significant difference in serum 25 (OH) D before and after treatment in the control group (P> 0.05). The serum 25 (OH) D level in the observation group was higher than that in the control group after treatment (P <0.05). Conclusions: Intravenous administration of vitamin D330 million IU intramuscularly to children with asthma can correct their deficiency or deficiency of 25 (OH) D, which may be an active supplementary treatment to improve the clinical prognosis of children with asthma.