以2-二乙氧基膦酰甲基-4,6-二甲氧基苯甲酸甲酯和芳香醛为原料,经缩合、脱甲基和水解反应制得3-羟基-5-甲氧基芪-2-羧酸衍生物1a~1e,并研究其对脂多糖诱导的RAW264.7巨噬细胞的抗炎作用。结果显示,化合物1c、1d和1e具有一定的抗炎作用,且对正常细胞的毒性较小。 Using 2-diethoxyphosphonomethyl-4,6-dimethoxybenzoic acid methyl ester and aromatic aldehyde as raw materials, condensation, demethylation and hydrolysis reaction of 3-hydroxy-5-methoxy Stilbene-2-carboxylic acid derivatives 1a-1e and their anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages. The results show that compounds 1c, 1d and 1e have a certain anti-inflammatory effect, and less toxic to normal cells.