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本研究对从广州郊区某乡的腹泻病人、健康人及环境（包括猪、鸡和环境）中分离到的产毒性大肠杆菌（ETEC）菌株进行了毒力型、耐药性及质粒分析。结果表明，病人ETEC株含LT或STp较多，环境株含LT较多。比较三种来源菌株对20种临床常用抗菌药物的耐药性，病人株的耐药谱最广，耐药率也最高；其次为环境株。根据耐药谱，可把大多数菌株（94％）分为6个型．不同来源ETEC株的优势耐药型有所不同，但不同毒力型ETEC株的耐药谱无明显不同。91．6％（55／60）的ETEC殊含有质粒，与正常大肠杆菌（78．6％）相近，最常见的质粒有2．2～2．6Md、3．3～4．5Md和＞20Md三种，ETEC株含＞20Md质粒显著高于正常大肠杆菌。未发现质粒谱与ETEC毒力型及耐药谱之间有明显的关系。
In this study, virulence, drug resistance and plasmid analysis of toxigenic Escherichia coli (ETEC) strains isolated from diarrhea patients, healthy people and the environment (including pigs, chickens and the environment) in a rural area of Guangzhou were studied. The results showed that patients with ETEC strains containing LT or STp more LT containing environmental strains more. The drug resistance of 20 strains of common antibacterials were compared among the three strains. The resistant strains of patients were the most widely and the resistant rate was the highest. According to the spectrum of resistance, most strains (94%) can be divided into 6 types. The dominant drug-resistant strains of ETEC strains from different sources are different, but there is no significant difference in the drug resistance spectrum of different strains of ETEC. 91.6% (55/60) of ETECs contained plasmids similar to those of normal Escherichia coli (78.6%). The most common plasmids were 2.2-2.6Md, 3.3-4.5Md and> 20Md Three kinds, ETEC containing> 20Md plasmid was significantly higher than normal E. coli. No significant relationship was found between the plasmid profile and the virulence and drug resistance spectrum of ETEC.