【摘 要】
：
目的探讨大肠癌组织中CD147的表达及其临床意义。方法将50例大肠癌手术标本、10例相应癌旁及14例正常大肠组织制成组织芯片,将17例活检腺瘤标本进行常规切片,应用免疫组化SAB
【机 构】
：
西北民族大学医院内科,兰州市城关区人民医院内科,兰州大学基础医学院
论文部分内容阅读
目的探讨大肠癌组织中CD147的表达及其临床意义。方法将50例大肠癌手术标本、10例相应癌旁及14例正常大肠组织制成组织芯片,将17例活检腺瘤标本进行常规切片,应用免疫组化SABC法研究CD147的表达。结果CD147在大肠癌组织中的阳性表达率为80%,明显高于正常大肠组织的35.7%,差异有统计学意义（P〈0.05）,大肠癌与腺瘤性息肉76.5%、癌旁70%之间差异无统计学意义。CD147的表达与Dukes分期、淋巴结转移有关（P〈0.05）,而与患者的性别、年龄及组织学分级无关。结论CD147在大肠癌
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