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目的探讨阿托伐他汀联合沙格列汀治疗2型糖尿病合并血脂异常的临床效果及安全性。方法选择医院收治的2型糖尿病合并血脂异常的患者62例,按治疗方法不同分为观察组与对照组,每组31例。观察组应用阿托伐他汀联合沙格列汀治疗,对照组仅给予沙格列汀治疗。观察2组治疗前后血脂、血糖及肝功能情况。结果治疗后观察组血脂水平改善情况优于对照组,差异有统计学意义(P<0.05)。治疗后2组血糖均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后2组肝功能指标比较差异无统计学意义(P>0.05)。结论阿托伐他汀联合沙格列汀治疗2型糖尿病合并血脂异常临床效果较好,可有效地改善患者糖、脂代谢紊乱情况,且不增加不良反应。
Objective To investigate the clinical efficacy and safety of atorvastatin combined with saxagliptin in the treatment of type 2 diabetes with dyslipidemia. Methods Sixty-two patients with type 2 diabetes mellitus and dyslipidemia admitted to the hospital were divided into observation group and control group according to different treatment methods, with 31 cases in each group. The observation group was treated with atorvastatin combined with saxagliptin, and the control group only with saxagliptin. The blood lipid, blood glucose and liver function of two groups before and after treatment were observed. Results After treatment, the improvement of blood lipid level in the observation group was better than that in the control group (P <0.05). The blood glucose of the two groups after treatment was lower than that before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in liver function index between the two groups after treatment (P> 0.05). Conclusions Atorvastatin combined with saxagliptin has good clinical efficacy in the treatment of type 2 diabetes with dyslipidemia, which can effectively improve the disorder of glucose and lipid metabolism in patients without any adverse reactions.