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目的:测定复方地塞米松滴眼液中地塞米松磷酸钠的含量。方法:用系数倍率法在240nm,255.5nm处不经分离直接测定地塞米松的含量,消除了羟苯乙酯及硫酸新霉素的干扰。结果:地塞米松在5～15μg·ml~(-1)范围内呈良好的线性关系,r=0.9998。平均回收率为100.6％,RSD为0.6％。结论:本法简便、快速、准确,适合于医院和药厂对本品的快速检验及质量控制。
Objective: To determine the content of dexamethasone sodium phosphate in compound dexamethasone eye drops. Methods: The content of dexamethasone was directly measured at 240nm and 255.5nm without any separation by the factor magnification method, and the interference of phenethyl ethyl and neomycin sulfate was eliminated. Results: Dexamethasone showed a good linearity in the range of 5 ~ 15μg · ml ~ (-1), r = 0.9998. The average recovery was 100.6% with a RSD of 0.6%. Conclusion: This method is simple, rapid and accurate, suitable for rapid testing and quality control of this product by hospitals and pharmaceutical companies.