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在1970年,Hall等介绍了一种新的β-肾上腺素能阻滞剂—噻吗心安。它与其他β-阻滞剂不同,既无拟交感神经作用又无局部麻醉作用。很适合于在长期治疗中局部使用。Katz等(1976)报告了在15个正常志愿者中,用0.5%,1.0%和1.5%噻吗心安点眼所得的结果,证明确可使眼压下降,用药后1或2小时作用最强,持续时间至少为7小时。Zimmerman等(1977)用噻吗心安治疗30名青光眼患者,与治疗前时照,点眼后7小时眼压
In 1970, Hall et al. Introduced a new beta-adrenergic blocker, timolol. Unlike other beta-blockers, it has neither sympathominal nor local anesthetic effects. Very suitable for long-term treatment in the local use. Katz et al. (1976) reported results of timolol 0.5%, 1.0%, and 1.5% timolol in 15 normal volunteers, demonstrating that intraocular pressure did indeed decrease and that 1 or 2 hours after dosing was the strongest, Duration of at least 7 hours. Zimmerman et al (1977) with timolol treatment of 30 patients with glaucoma, with pre-treatment according to the time, 7 hours after the point of eye intraocular pressure