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背景:胰岛内分泌细胞,尤其是分化为胰岛β细胞,为解决糖尿病的胰岛供体短缺提供有效途径。目的:文章将对胚胎干细胞分化为胰腺内分泌细胞过程中参与的主要转录因子及其相关机制进行概述,为治疗糖尿病奠定理论基础。方法:由第一作者于2009-09应用计算机检索PubMed数据库相关文献。检索时间范围:1997/2009。检索关键词为“Embryonicstemcells;Transcriptionfactors;Pancreaticendocrinecells”。纳入与胚胎干细胞分化为胰腺内分泌细胞的主要转录因子及其相关机制研究相关的内容。排除重复文献。阅读标题和摘要进行筛选,共纳入32篇用于综述。结果与结论:胰腺内分泌细胞是胰腺的主要分泌部位,可分泌胰高血糖素、胰岛素、生长抑素、胰多肽和胃促生长素等,这些激素在调节血糖浓度中有着重要作用。胚胎干细胞是一种多潜能干细胞,可分化为胰腺内分泌细胞,在分化过程中受到多种基因和转录因子的调控参与,但目前人们对转录因子的研究仅局限于单个转录因子,对于胰腺发生发育过程中的调节网络研究还需要进一步深入和完善。
Background: Endocrine cells, especially the islet β cells, provide an effective way to solve the shortage of islet donor in diabetes. Objective: The article summarizes the major transcription factors involved in the process of embryonic stem cells differentiating into pancreatic endocrine cells and their related mechanisms, laying a theoretical foundation for the treatment of diabetes mellitus. METHODS: PubMed database was searched by the first author on 2009-09 computer. Retrieval time range: 1997/2009. Search keywords for “Embryonicstemcells; Transcriptionfactors; Pancreaticendocrinecells ”. It is involved in the study of the major transcription factors that differentiate embryonic stem cells into pancreatic endocrine cells and related mechanisms. Exclude duplicate documents. Read the title and summary of screening, a total of 32 for review. RESULTS AND CONCLUSION: Pancreatic endocrine cells are the major secretion site of the pancreas and can secrete glucagon, insulin, somatostatin, pancreatic polypeptide and ghrelin. These hormones play an important role in the regulation of blood glucose concentration. Embryonic stem cells are pluripotent stem cells that can differentiate into pancreatic endocrine cells and are involved in the regulation of many genes and transcription factors during differentiation. However, the research on transcription factors is limited to a single transcription factor, The process of regulating network research needs to be further deepened and improved.