1846年Soberro首先合成了硝酸甘油,1879年Murrell推荐用于治疗心绞痛,至今临床应用已有100多年历史。硝酸甘油最常用的给药途径为舌下含服,能缓解心绞痛,也可用于防止心绞痛发作,起效快、方便、经济及可重复应用,但舌下给药药物效应持续短,剂量不易掌握,易引起低血压和反射性心动过速,效应不恒定。 Soberro first synthesized nitroglycerin in 1846, and Murrell was recommended for the treatment of angina in 1879, which has been in clinical use for more than 100 years. The most commonly used route of administration of nitroglycerin is sublingual, which can relieve angina pectoris. It can also be used to prevent the onset of angina pectoris, has rapid onset, is convenient, economical and reusable. However, the drug effect of sublingual administration is short and dosage is not easy to grasp , Easily lead to hypotension and reflex tachycardia, the effect is not constant.