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目的:通过测定不同动脉粥样硬化(AS)程度受试者的血浆内脏脂肪素(Visfatin)水平并评估内皮功能状态,探讨血浆Visfatin在AS发生发展及血管内皮功能紊乱中的意义。方法:62例接受冠状动脉造影和颈总动脉、肱动脉超声检测的患者,采用Gensini积分系统和测定颈总动脉内-中膜厚度(IMT)评价AS严重程度后分为对照组、早期AS组、严重AS组。采用超声检测肱动脉血流介导的血管扩张(FMD)评估各组血管内皮功能。同时检测各组血浆Visfatin水平,并将其与颈总动脉IMT、冠状动脉Gensini积分及肱动脉FMD进行相关性分析。结果:①与对照组比较,AS组血浆Visfatin水平显著升高,且严重AS组高于早期AS组(P<0.01);②血浆Visfatin水平与颈总动脉IMT呈正相关(r=0.475;P<0.01);③血浆Visfatin水平与冠状动脉Gensini积分呈正相关(r=0.359;P<0.01);④血浆Visfatin水平与肱动脉FMD呈负相关(r=-0.488;P<0.01)。结论:血浆Visfatin水平与AS的发生和发展密切相关。AS患者血浆Visfatin水平的高低能初步反映血管内皮功能受损的状况和AS的严重程度,提示血浆Visfatin水平可能是一个新的心血管疾病预测因子。
Objective: To investigate the significance of plasma Visfatin in the development of AS and vascular endothelial dysfunction by measuring plasma visfatin (Visfatin) levels and evaluating endothelial function in subjects with different degree of atherosclerosis (AS). Methods: Sixty-two patients who underwent coronary angiography, carotid artery and brachial artery ultrasound were divided into control group, early AS group, Gensini score system and carotid arterial intima-media thickness (IMT) , Severe AS group. The brachial artery-mediated vasodilatation (FMD) was used to evaluate the vascular endothelial function in each group. At the same time, the levels of Visfatin in each group were detected and the correlations were analyzed with IMT of carotid artery, Gensini score of coronary artery and FMD of brachial artery. Results: ① Compared with the control group, the levels of Visfatin in the AS group were significantly higher than those in the control group, and the levels of Visfatin in the severe AS group were significantly higher than those in the early AS group (P <0.01); ② Visfatin level was positively correlated with the IMT of the common carotid artery (r = 0.475, P < 0.01). The level of Visfatin in plasma was positively correlated with Gensini score of coronary artery (r = 0.359; P <0.01). The level of Visfatin in plasma was negatively correlated with FMD of brachial artery (r = -0.488, P <0.01). Conclusion: Plasma Visfatin level is closely related to the occurrence and development of AS. The level of Visfatin in plasma of AS patients can initially reflect the status of vascular endothelial dysfunction and the severity of AS, suggesting that plasma Visfatin level may be a new predictor of cardiovascular disease.