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肺源性心脏病(肺心病)患病率每年上升6～7%.此病治疗困难,近来年提倡早期进行综合治疗.为降低肺动脉压,采用扩血管药,主要用硝酸盐类药物.作者研究了硝酸山梨醇对肺心病患者的血流动力学、外呼吸功能、肺通气血流比率、血气和酸碱平衡的影响.研究对象为124例慢性肺心病患者(男3,女121,年龄20～60岁)。将病人分为两组,Ⅰ组为76例心功能代偿期患者;Ⅱ组为48例心功能失代偿期患者;对照组为25例健康人(年龄20～40岁)。在肺部炎症消失后,舌下1次含用硝酸甘油0.5mg,试其耐受性后,用硝酸山梨醇进行药效试验。于用药
The prevalence of pulmonary heart disease (pulmonary heart disease) increased by 6 ~ 7% per year. The treatment of this disease is difficult, in recent years to promote early comprehensive treatment. To reduce pulmonary artery pressure, the use of vasodilator drugs, mainly nitrate drugs. The effects of sorbitol on the hemodynamics, external respiration, pulmonary ventilation rate, blood gas and acid-base balance in patients with cor pulmonale were studied.The study included 124 patients with chronic cor pulmonale (male 3, female 121, age 20 ~ 60 years old). The patients were divided into two groups. Group Ⅰ was 76 patients with decompensated cardiac function. Group Ⅱ was 48 patients with decompensated cardiac function. The control group was 25 healthy people (aged 20-40 years). After the disappearance of lung inflammation, sublingual nitroglycerin 0.5mg, test its tolerance, with nitric acid sorbitol for efficacy test. In medication